In today's day and age, it becomes more important for deliberate engagement, particularly if you want to create the intrinsic motivation to work on a specific area.
Show that you can add value to the organisation, and show that you have the right values to carry out the role.
If you are looking for a change in career trajectory, say so. If you are searching for better prospects, say it too. If you do not know much about the position, be open about it.
Do not confuse an interview with a casual chat session. Take the interview seriously.
If there is one key point to draw from this, it is this: we cannot predict the future, but we need to prepare for any futures.